Propolis cinnamic acid derivatives induce apoptosis through both
extrinsic and intrinsic apoptosis signaling pathways and modulate of miRNA
expression
Volume 21, Issues 8–9, July–August 2014, Pages 1070–1077
Propolis cinnamic acid derivatives have a number of biological
activities including anti-oxidant and anti-cancer ones. In this study, we aimed
to elucidate the mechanism of the anti-cancer activity of 3 representative
propolis cinnamic acid derivatives, i.e., Artepilin C, Baccharin and Drupanin
in human colon cancer cell lines. Our study demonstrated that these compounds
had a potent apoptosis-inductive effect even on drug-resistant colon cancer
cells. Combination treatment of human colon cancer DLD-1 cells with 2 of these
compounds, each at its IC20 concentration, induced apoptosis by stimulating
both intrinsic and extrinsic apoptosis signaling pathways. Especially,
Baccharin plus Drupanin exhibited a synergistic growth-inhibitory effect by
strengthening both intrinsic and extrinsic apoptotic signaling transduction
through TRAIL/DR4/5 and/or FasL/Fas death-signaling loops and by increasing the
expression level of miR-143, resulting in decreased expression levels of the
target gene MAPK/Erk5 and its downstream target c-Myc.
These data suggest that the supplemental intake of these
compounds found in propolis has enormous significance with respect to cancer
prevention.
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